Histology of Basophil |Histology|


Ok, now, we will talk about Basophils.

1) Basophil is the rarest leukocytes found in a normal blood smear
2) Large amount of granules, they even compressed against its cell membrane giving its angular appearance
3) The granules are stained by hematoxylin – acidic in nature
4) Have numerous receptors including IgE receptors
5) Involved in hypersensitivity response (in contrast with eosinophil)
6) Have almost  similar activity like mast cells but they are considered as different cause having different progenitor cell

Basophilic Granules
1) Its granules are stained by basic dye (hemotoxylin) due to the presence of heparin (acidic in nature)
2) Specific granules of basophil are less and irregular in shape
3) Basophilic granules contained

Basophil formation is more or less the same like other grabulocytes as it shares same progenitor cells of CFU-S. It is also controlled by cytokine like Colony Stimulating Factor (CSF). Following is diagram of basophil formation

Pluripotent Heamopoeitic Stem Cell –> CFU-S –> CFS-basophil –> Myeloblast –> Promyelocyte –> Basophil myelocyte –> Basophil metamyelocyte –> Stab cell –> Basophil

Those are all about basophil.
Thank you =))


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